After maturation, in primary lymphoid organs, thelymphocytes migrate for interaction with antigens tosecondary lymphoid organ(s)/tissue(s) like:A. thymusB. bone marrowC. spleenD. lymph nodesE. Peyer’s patchesChoose the correct answer from the options givenbelow:

Answer
✅ Correct Option: (4) C, D, E only
Immune System Overview: The immune system is divided into primary and secondary lymphoid organs, each having a distinct role in lymphocyte development and function.
🧪 Primary Lymphoid Organs
These are the sites where lymphocytes mature and become antigen-sensitive:
- Bone marrow – site of B cell maturation
- Thymus – site of T cell maturation
These are not involved in direct antigen interaction.
🛡️ Secondary Lymphoid Organs / Tissues
After maturation, lymphocytes migrate to these sites to encounter antigens and initiate immune responses:
- Spleen
- Lymph nodes
- Peyer’s patches (in small intestine)
These are the sites of antigen–lymphocyte interaction where effector cells are formed.
📌 Final Matching:
- A. Thymus – Primary
- B. Bone marrow – Primary
- C. Spleen – Secondary
- D. Lymph nodes – Secondary
- E. Peyer’s patches – Secondary
✅ Therefore, the correct answer is:
(4) C, D, E only
